Stocks · Healthcare · Biotechnology
Madrigal Pharmaceuticals, Inc. MDGL
$499.40 -0.06% Close, Oct 2, 2026 · NASDAQ · Market cap $11.54B
Low risk
Next earnings report: Nov 3, 2026
Scroll or pinch to zoom, drag to move. Daily prices adjusted for splits. Markers: E = earnings (green beat, red miss), S = split, D = dividend.
Three things to know
- Revenue over the last four quarters was $1.28B, up 149.0% from a year earlier, slowing from 256.8% a quarter earlier.
- Operating margin widened to -25.1% from -60.1% a year earlier.
- The diluted share count rose 31.2% in a year.
PromtFinance scores
Each score is a percentile within the Healthcare sector (0–100). Under each score: how the stock ranks in its sector on every component. As of Oct 5, 2026.
How fast revenue, earnings and cash flow are growing.
- Revenue growth (TTM, YoY)Top 8%
- Revenue growth accelerationBottom 4%
Returns on capital, margins, earnings quality and balance-sheet strength.
- Return on invested capitalBottom 36%
- Gross marginTop 17%
- Operating marginBottom 41%
- Accruals (lower is better)Top 34%
- Interest coverBottom 27%
How cheap the shares are relative to earnings, cash flow and their own history.
- Earnings yieldTop 38%
- Free-cash-flow yieldTop 41%
- EBITDA / enterprise valueTop 45%
- Sales / enterprise valueBottom 33%
Strength and persistence of the price trend, including versus the S&P 500.
- 12-month return excluding last monthTop 50%
- 6-month returnBottom 33%
- 1-year return vs S&P 500Bottom 49%
- Distance from 52-week highTop 30%
- Trend checklist (0–4)Bottom 38%
Earnings surprises and analyst sentiment (estimate-revision history is being collected).
- Average EPS surprise, last 4 quartersBottom 5%
- Consecutive EPS beatsTop 35%
- Share of analysts rating BuyTop 30%
- Upside to consensus price targetBottom 38%
Low volatility, shallow drawdowns, low market sensitivity and modest leverage.
- Volatility, 60 days (lower is better)Top 23%
- Maximum drawdown, 3 yearsTop 5%
- Beta vs S&P 500 (lower is better)Top 7%
What changed
Latest four quarters versus the same period a year earlier (growth: versus one quarter earlier).
| Measure | Before | Now | |
|---|---|---|---|
| Revenue growth (YoY) | 256.8% | 149.0% | ↓ |
| Gross margin | 96.3% | 91.5% | ↓ |
| Operating margin | -60.1% | -25.1% | ↑ |
| FCF margin | -59.8% | -16.1% | ↑ |
Fundamental momentum
| Measure | Now (TTM) | Year / quarter before | Sector rank | |
|---|---|---|---|---|
| Revenue growth (TTM, YoY) | 149.0% | 256.8% | ↓ | Top 8% |
| Gross margin | 91.5% | 96.3% | ↓ | Top 17% |
| Operating margin | -25.1% | -60.1% | ↑ | Bottom 41% |
| Net margin | -25.3% | -54.7% | ↑ | — |
| Free-cash-flow margin | -16.1% | -59.8% | ↑ | — |
| Return on invested capital | -37.0% | — | Bottom 36% |
Quality of earnings and balance sheet
- Accruals (net income − OCF) / assetsLower is better; high accruals can signal weaker earnings quality.
- -10.2%
- Stock-based compensation / revenueA cost to shareholders through dilution.
- 7.4%
- Receivables growth vs revenue growthReceivables growing much faster than sales can be a warning.
- -6.3 pp
- Interest cover (operating income / interest)How many times operating profit covers interest.
- -20.6×
Shareholder returns
- Dividend yield (dividends paid, TTM)
- 0.00%
- Net buyback yield (TTM)
- -0.29%
- Shareholder yield
- -0.29%
- Share count change, 1 year
- +31.2%
- Share count change, 3-year CAGR
- +16.8%
Shareholder yield = dividends + net buybacks over the last four quarters, divided by market cap.
Based on the four quarters through Jun 30, 2026 (filed Jul 30, 2026).
Earnings and expectations
Earnings momentum
- Consecutive EPS beats
- 2
- Beats in the last 8 reports
- 6 of 8
- Average EPS surprise, last 4
- -100.0%
- Average 2-day reaction, last 8
- +4.5%
- Positive 20 days after report
- 4 of 8
Analysts
- Consensus price target
- $680.38
- Target vs current price
- +36.2%
- Analysts with a rating
- 25
- Share rating Buy or Strong Buy
- 88%
- Consensus rating
- Buy
How the stock reacted to recent reports
| Report date | EPS surprise | 2 days | 5 days | 20 days | 60 days |
|---|---|---|---|---|---|
| Jul 30, 2026 | +25.7% | -9.8% | -6.0% | -1.5% | — |
| May 6, 2026 | +10.0% | +7.4% | +1.6% | -2.8% | -7.0% |
| Feb 19, 2026 | -6525.0% | -11.1% | -11.5% | -10.1% | +9.8% |
| Nov 4, 2025 | -149.4% | +7.8% | +20.3% | +39.0% | +18.7% |
| Aug 5, 2025 | +45.4% | +8.6% | +12.0% | +39.7% | +37.5% |
| May 1, 2025 | +8.3% | -1.9% | -10.5% | -19.2% | -11.9% |
| Feb 26, 2025 | +37.3% | +15.0% | +3.8% | +10.9% | -10.4% |
| Oct 31, 2024 | +29.1% | +20.1% | +56.6% | +53.5% | +51.1% |
Returns from the close before each report. Past reactions do not determine future ones.
Earnings history
| Report date | EPS | Estimate | Surprise | Revenue |
|---|---|---|---|---|
| Jul 30, 2026 | -$1.99 | -$2.68 | +25.7% | $364.3M |
| May 6, 2026 | -$3.25 | -$3.61 | +10.0% | $311.3M |
| Feb 19, 2026 | -$2.57 | $0.04 | -6525.0% | $321.1M |
| Nov 4, 2025 | -$5.08 | -$2.04 | -149.4% | $287.3M |
| Aug 5, 2025 | -$1.90 | -$3.48 | +45.4% | $212.8M |
| May 1, 2025 | -$3.32 | -$3.62 | +8.3% | $137.3M |
| Feb 26, 2025 | -$2.71 | -$4.32 | +37.3% | $103.3M |
| Oct 31, 2024 | -$4.92 | -$6.94 | +29.1% | $62.2M |
Valuation in context
| Multiple | Now | 5-year median | 5-year percentile | Sector rank (cheapness) |
|---|---|---|---|---|
| EV / Sales | 9.03× | — | — | Bottom 33% |
| Free-cash-flow yield | -1.79% | — | — | Top 41% |
| Earnings yield | -2.58% | — | — | Top 38% |
Technical state
Trend checklist
- ✗ Price above 20-day average
- ✗ Price above 50-day average
- ✗ Price above 200-day average
- ✓ 50-day average above 200-day
- ✗ MACD histogram positive
Trend quality
- Days above the 50-day average
- 0
- Days above the 200-day average
- 0
- 50-day average slope (20 days)
- -1.1%
- 200-day average slope (20 days)
- -0.9%
- Distance from 50-day average
- -4.6%
- Distance from 200-day average
- -2.2%
- RSI (14)
- 36.5
- Relative volume
- 1.27×
Risk and drawdowns
- Volatility, 60 days (annualized)
- 40.5%
- Volatility vs own 5-year history
- 6th percentile · Low for this stock
- Beta vs S&P 500 (2 years, weekly)
- 0.25
- Correlation with S&P 500
- 0.07
- Current drawdown from 1-year high
- -17.2%
- Maximum drawdown, 3 years
- -31.7%
Largest declines in the past six years
| From peak | To low | Decline | Length | Recovery |
|---|---|---|---|---|
| Apr 28, 2023 | Oct 27, 2023 | -61.4% | 126 days | 255 days (Nov 1, 2024) |
| Apr 29, 2021 | Jan 27, 2022 | -59.4% | 189 days | 225 days (Dec 19, 2022) |
| Dec 22, 2025 | Mar 3, 2026 | -29.4% | 47 days | Not yet recovered |
| Feb 26, 2025 | May 23, 2025 | -24.8% | 61 days | 54 days (Aug 12, 2025) |
| Feb 23, 2023 | Mar 22, 2023 | -24.8% | 19 days | 24 days (Apr 26, 2023) |
Declines of 10% or more from a closing high, measured on daily closes.
Financial statements
- Market cap
- $11.54B
- EPS, diluted (TTM)
- -$12.89
- Revenue (TTM)
- $1.28B
- 52-week range
- $393.61 – $615.00
| FY 2021 | FY 2022 | FY 2023 | FY 2024 | FY 2025 | |
|---|---|---|---|---|---|
| Revenue | $0 | $0 | $0 | $180.1M | $958.4M |
| Gross profit | $0 | $0 | $0 | $173.9M | $902.3M |
| Operating income | -$242.5M | -$293.6M | -$380.5M | -$497.9M | -$300.1M |
| Net income | -$241.8M | -$295.4M | -$373.6M | -$465.9M | -$288.3M |
| EPS (diluted) | -$14.63 | -$17.23 | -$19.99 | -$21.90 | -$12.85 |
| Q3 2024 | Q4 2024 | Q1 2025 | Q2 2025 | Q3 2025 | Q4 2025 | Q1 2026 | Q2 2026 | |
|---|---|---|---|---|---|---|---|---|
| Revenue | $62.2M | $103.3M | $137.3M | $212.8M | $287.3M | $321.1M | $311.3M | $364.3M |
| Net income | -$107.0M | -$59.4M | -$73.2M | -$42.3M | -$114.2M | -$58.6M | -$94.4M | -$57.9M |
| EPS (diluted) | -$4.92 | -$2.71 | -$3.32 | -$1.90 | -$5.08 | -$2.57 | -$3.25 | -$1.99 |
| FY 2021 | FY 2022 | FY 2023 | FY 2024 | FY 2025 | |
|---|---|---|---|---|---|
| Operating cash flow | -$183.9M | -$224.9M | -$324.2M | -$455.6M | -$189.6M |
| Capital expenditure | -$209,000 | -$217,000 | -$1.5M | -$1.5M | -$467,000 |
| Free cash flow | -$184.1M | -$225.1M | -$325.7M | -$457.0M | -$190.0M |
| Dividends paid | $0 | $0 | $0 | $0 | $0 |
| Net share buybacks | $170.2M | $255.4M | $260.2M | $397.5M | $38.1M |
Cash outflows are shown as negative numbers.
- Cash and short-term investments
- $838.8M
- Total assets
- $1.24B
- Total liabilities
- $720.9M
- Total debt
- $347.8M
- Net debt
- $55.0M
- Shareholders’ equity
- $523.7M
As of Jun 30, 2026 (filed Jul 30, 2026).
Short interest
- Shares sold short
- 2,254,423
- Days to cover
- 11.42
- Change vs previous report
- +0.6%
FINRA short interest, settlement date Sep 15, 2026.
Stock splits
- Jul 25, 2016
- 1-for-35