Stocks · Healthcare · Biotechnology
Prime Medicine, Inc. PRME
$2.98 -0.33% Close, Oct 2, 2026 · NASDAQ · Market cap $538.2M
Weak trendExpensive vs sectorHigh risk
Next earnings report: Nov 6, 2026
Scroll or pinch to zoom, drag to move. Daily prices adjusted for splits. Markers: E = earnings (green beat, red miss), S = split, D = dividend.
Three things to know
- Operating margin narrowed to -4824.9% from -4116.6% a year earlier.
- The diluted share count rose 37.2% in a year.
- Over the past year the stock returned -46.7%, behind the S&P 500 by 61.8 percentage points.
PromtFinance scores
Each score is a percentile within the Healthcare sector (0–100). Under each score: how the stock ranks in its sector on every component. As of Oct 5, 2026.
How fast revenue, earnings and cash flow are growing.
- Revenue growth (TTM, YoY)Bottom 16%
- Revenue growth accelerationBottom 11%
Returns on capital, margins, earnings quality and balance-sheet strength.
- Return on invested capitalBottom 13%
- Gross marginBottom 2%
- Operating marginBottom 7%
- Accruals (lower is better)Top 26%
How cheap the shares are relative to earnings, cash flow and their own history.
- Earnings yieldBottom 20%
- Free-cash-flow yieldBottom 17%
- EBITDA / enterprise valueBottom 22%
- Sales / enterprise valueBottom 7%
Strength and persistence of the price trend, including versus the S&P 500.
- 12-month return excluding last monthBottom 13%
- 6-month returnBottom 31%
- 1-year return vs S&P 500Bottom 11%
- Distance from 52-week highBottom 20%
- Trend checklist (0–4)Bottom 14%
Earnings surprises and analyst sentiment (estimate-revision history is being collected).
- Average EPS surprise, last 4 quartersBottom 37%
- Consecutive EPS beatsBottom 49%
- Share of analysts rating BuyBottom 39%
- Upside to consensus price targetTop 26%
Low volatility, shallow drawdowns, low market sensitivity and modest leverage.
- Volatility, 60 days (lower is better)Bottom 19%
- Maximum drawdown, 3 yearsBottom 19%
- Beta vs S&P 500 (lower is better)Bottom 3%
What changed
Latest four quarters versus the same period a year earlier (growth: versus one quarter earlier).
| Measure | Before | Now | |
|---|---|---|---|
| Revenue growth (YoY) | 4.9% | -17.9% | ↓ |
| Gross margin | 62.4% | -1025.6% | ↓ |
| Operating margin | -4116.6% | -4824.9% | ↓ |
| FCF margin | -2156.8% | -3850.9% | ↓ |
Fundamental momentum
| Measure | Now (TTM) | Year / quarter before | Sector rank | |
|---|---|---|---|---|
| Revenue growth (TTM, YoY) | -17.9% | 4.9% | ↓ | Bottom 16% |
| Gross margin | -1025.6% | 62.4% | ↓ | Bottom 2% |
| Operating margin | -4824.9% | -4116.6% | ↓ | Bottom 7% |
| Net margin | -4613.1% | -4016.8% | ↓ | — |
| Free-cash-flow margin | -3850.9% | -2156.8% | ↓ | — |
| Return on invested capital | -86.8% | — | Bottom 13% |
Quality of earnings and balance sheet
- Accruals (net income − OCF) / assetsLower is better; high accruals can signal weaker earnings quality.
- -12.8%
- Stock-based compensation / revenueA cost to shareholders through dilution.
- 657.3%
- Receivables growth vs revenue growthReceivables growing much faster than sales can be a warning.
- -82.1 pp
Shareholder returns
- Dividend yield (dividends paid, TTM)
- 0.00%
- Net buyback yield (TTM)
- -0.10%
- Shareholder yield
- -0.10%
- Share count change, 1 year
- +37.2%
- Share count change, 3-year CAGR
- +25.1%
Shareholder yield = dividends + net buybacks over the last four quarters, divided by market cap.
Based on the four quarters through Jun 30, 2026 (filed Aug 6, 2026).
Earnings and expectations
Earnings momentum
- Consecutive EPS beats
- 1
- Beats in the last 8 reports
- 3 of 8
- Average EPS surprise, last 4
- -3.1%
- Average 2-day reaction, last 8
- -5.6%
- Positive 20 days after report
- 2 of 8
Analysts
- Consensus price target
- $7.50
- Target vs current price
- +151.7%
- Analysts with a rating
- 10
- Share rating Buy or Strong Buy
- 70%
- Consensus rating
- Buy
How the stock reacted to recent reports
| Report date | EPS surprise | 2 days | 5 days | 20 days | 60 days |
|---|---|---|---|---|---|
| Aug 6, 2026 | +6.7% | -4.2% | +3.9% | +19.2% | — |
| May 7, 2026 | -16.7% | -8.5% | -4.1% | +1.8% | -17.6% |
| Mar 3, 2026 | +12.0% | -9.2% | -11.8% | -32.4% | -29.2% |
| Nov 7, 2025 | -14.3% | -8.9% | -20.3% | -10.5% | -16.7% |
| Aug 7, 2025 | -13.9% | -9.6% | -6.4% | -16.5% | +6.9% |
| May 8, 2025 | -25.0% | -7.0% | -14.8% | -4.2% | +216.9% |
| Feb 28, 2025 | +16.2% | +4.1% | -5.0% | -17.4% | -46.7% |
| Nov 12, 2024 | -2.3% | -1.6% | -27.6% | -26.7% | -44.9% |
Returns from the close before each report. Past reactions do not determine future ones.
Earnings history
| Report date | EPS | Estimate | Surprise | Revenue |
|---|---|---|---|---|
| Aug 6, 2026 | -$0.24 | -$0.26 | +6.7% | $1.2M |
| May 7, 2026 | -$0.28 | -$0.24 | -16.7% | $856,000 |
| Mar 3, 2026 | -$0.22 | -$0.25 | +12.0% | $842,000 |
| Nov 7, 2025 | -$0.32 | -$0.28 | -14.3% | $1.2M |
| Aug 7, 2025 | -$0.41 | -$0.36 | -13.9% | $1.1M |
| May 8, 2025 | -$0.40 | -$0.32 | -25.0% | $1.5M |
| Feb 28, 2025 | -$0.31 | -$0.37 | +16.2% | $2.2M |
| Nov 12, 2024 | -$0.44 | -$0.43 | -2.3% | $209,000 |
Valuation in context
| Multiple | Now | 5-year median | 5-year percentile | Sector rank (cheapness) |
|---|---|---|---|---|
| EV / Sales | 148.11× | — | — | Bottom 7% |
| Free-cash-flow yield | -29.14% | — | — | Bottom 17% |
| Earnings yield | -36.91% | — | — | Bottom 20% |
Technical state
Trend checklist
- ✗ Price above 20-day average
- ✗ Price above 50-day average
- ✗ Price above 200-day average
- ✗ 50-day average above 200-day
- ✗ MACD histogram positive
Trend quality
- Days above the 50-day average
- 0
- Days above the 200-day average
- 0
- 50-day average slope (20 days)
- -4.6%
- 200-day average slope (20 days)
- -1.8%
- Distance from 50-day average
- -7.5%
- Distance from 200-day average
- -14.4%
- RSI (14)
- 43.3
- Relative volume
- 0.63×
Risk and drawdowns
- Volatility, 60 days (annualized)
- 78.9%
- Volatility vs own 5-year history
- 28th percentile · Normal for this stock
- Beta vs S&P 500 (2 years, weekly)
- 2.78
- Correlation with S&P 500
- 0.41
- Current drawdown from 1-year high
- -55.3%
- Maximum drawdown, 3 years
- -88.0%
Largest declines in the past six years
| From peak | To low | Decline | Length | Recovery |
|---|---|---|---|---|
| Nov 11, 2022 | Apr 8, 2025 | -94.5% | 601 days | Not yet recovered |
| Nov 1, 2022 | Nov 7, 2022 | -14.1% | 4 days | 4 days (Nov 11, 2022) |
Declines of 10% or more from a closing high, measured on daily closes.
Financial statements
- Market cap
- $538.2M
- EPS, diluted (TTM)
- -$1.10
- Revenue (TTM)
- $4.1M
- 52-week range
- $2.67 – $6.94
| FY 2021 | FY 2022 | FY 2023 | FY 2024 | FY 2025 | |
|---|---|---|---|---|---|
| Revenue | $0 | $0 | $0 | $3.0M | $4.6M |
| Gross profit | $0 | $0 | $0 | $3.0M | -$2.7M |
| Operating income | -$84.5M | -$116.5M | -$204.8M | -$202.5M | -$208.3M |
| Net income | -$165.4M | -$121.8M | -$198.1M | -$195.9M | -$201.1M |
| EPS (diluted) | -$1.92 | -$1.46 | -$2.18 | -$1.65 | -$1.35 |
| Q3 2024 | Q4 2024 | Q1 2025 | Q2 2025 | Q3 2025 | Q4 2025 | Q1 2026 | Q2 2026 | |
|---|---|---|---|---|---|---|---|---|
| Revenue | $209,000 | $2.2M | $1.5M | $1.1M | $1.2M | $838,000 | $856,000 | $1.2M |
| Net income | -$52.5M | -$42.3M | -$51.9M | -$52.6M | -$50.6M | -$46.1M | -$49.1M | -$42.1M |
| EPS (diluted) | -$0.44 | -$0.36 | -$0.40 | -$0.41 | -$0.32 | -$0.26 | -$0.28 | -$0.24 |
| FY 2021 | FY 2022 | FY 2023 | FY 2024 | FY 2025 | |
|---|---|---|---|---|---|
| Operating cash flow | -$34.1M | -$131.8M | -$165.4M | -$122.9M | -$162.6M |
| Capital expenditure | -$4.2M | -$16.1M | -$8.7M | -$7.3M | -$4.5M |
| Free cash flow | -$38.2M | -$147.9M | -$174.1M | -$130.2M | -$167.1M |
| Dividends paid | $0 | $0 | $0 | $0 | $0 |
| Net share buybacks | $270.4M | $185.3M | $655,000 | $170.1M | $139.5M |
Cash outflows are shown as negative numbers.
- Cash and short-term investments
- $95.1M
- Total assets
- $249.0M
- Total liabilities
- $209.2M
- Total debt
- $112.5M
- Net debt
- $65.0M
- Shareholders’ equity
- $39.8M
As of Jun 30, 2026 (filed Aug 6, 2026).
Dividends
| Ex-date | Amount | Paid |
|---|---|---|
| Mar 22, 2018 | $0.01 | Mar 29, 2018 |
Short interest
- Shares sold short
- 32,132,218
- Days to cover
- 12.31
- Change vs previous report
- -12.6%
FINRA short interest, settlement date Sep 15, 2026.