Stocks · Healthcare · Biotechnology
Septerna Inc SEPN
$37.71 -0.89% Close, Oct 2, 2026 · NASDAQ · Market cap $1.70B
Strong growthHigh qualityStrong trendHigh risk
Next earnings report: Nov 9, 2026
Scroll or pinch to zoom, drag to move. Daily prices adjusted for splits. Markers: E = earnings (green beat, red miss), S = split, D = dividend.
Three things to know
- Revenue over the last four quarters was $98.9M, up 13520.1% from a year earlier, accelerating from 7295.6% a quarter earlier.
- Operating margin widened to -44.0% from -14071.1% a year earlier.
- Over the past year the stock returned +98.5%, ahead of the S&P 500 by 83.4 percentage points.
PromtFinance scores
Each score is a percentile within the Healthcare sector (0–100). Under each score: how the stock ranks in its sector on every component. As of Oct 5, 2026.
How fast revenue, earnings and cash flow are growing.
- Revenue growth (TTM, YoY)Top 1%
- Revenue growth accelerationTop 1%
Returns on capital, margins, earnings quality and balance-sheet strength.
- Return on invested capitalTop 42%
- Gross marginTop 6%
- Operating marginBottom 36%
- Accruals (lower is better)Top 11%
How cheap the shares are relative to earnings, cash flow and their own history.
- Earnings yieldTop 33%
- Free-cash-flow yieldTop 14%
- EBITDA / enterprise valueTop 44%
- Sales / enterprise valueBottom 23%
Strength and persistence of the price trend, including versus the S&P 500.
- 12-month return excluding last monthTop 18%
- 6-month returnTop 19%
- 1-year return vs S&P 500Top 15%
- Distance from 52-week highTop 41%
- Trend checklist (0–4)Top 39%
Earnings surprises and analyst sentiment (estimate-revision history is being collected).
- Average EPS surprise, last 4 quartersBottom 25%
- Consecutive EPS beatsTop 35%
- Share of analysts rating BuyTop 10%
- Upside to consensus price targetBottom 37%
Low volatility, shallow drawdowns, low market sensitivity and modest leverage.
- Volatility, 60 days (lower is better)Bottom 33%
- Maximum drawdown, 3 yearsBottom 29%
- Beta vs S&P 500 (lower is better)Bottom 11%
What changed
Latest four quarters versus the same period a year earlier (growth: versus one quarter earlier).
| Measure | Before | Now | |
|---|---|---|---|
| Revenue growth (YoY) | 7295.6% | 13520.1% | ↑ |
| Gross margin | 100.0% | 99.6% | ↓ |
| Operating margin | -14071.1% | -44.0% | ↑ |
| FCF margin | -11436.9% | 106.3% | ↑ |
Fundamental momentum
| Measure | Now (TTM) | Year / quarter before | Sector rank | |
|---|---|---|---|---|
| Revenue growth (TTM, YoY) | 13520.1% | 7295.6% | ↑ | Top 1% |
| Gross margin | 99.6% | 100.0% | ↓ | Top 6% |
| Operating margin | -44.0% | -14071.1% | ↑ | Bottom 36% |
| Net margin | -24.5% | -12053.0% | ↑ | — |
| Free-cash-flow margin | 106.3% | -11436.9% | ↑ | — |
| Return on invested capital | -8.9% | — | Top 42% |
Quality of earnings and balance sheet
- Accruals (net income − OCF) / assetsLower is better; high accruals can signal weaker earnings quality.
- -23.0%
- Stock-based compensation / revenueA cost to shareholders through dilution.
- 16.5%
- Receivables growth vs revenue growthReceivables growing much faster than sales can be a warning.
- -12999.0 pp
- Net debt / EBITDABelow 1× is conservative; above 3× is high leverage.
- Net cash
Shareholder returns
- Dividend yield (dividends paid, TTM)
- 0.00%
- Net buyback yield (TTM)
- -1.08%
- Shareholder yield
- -1.08%
- Share count change, 1 year
- +2.0%
Shareholder yield = dividends + net buybacks over the last four quarters, divided by market cap.
Based on the four quarters through Jun 30, 2026 (filed Aug 10, 2026).
Earnings and expectations
Earnings momentum
- Consecutive EPS beats
- 2
- Beats in the last 8 reports
- 3 of 8
- Average EPS surprise, last 4
- -14.3%
- Average 2-day reaction, last 8
- +0.2%
- Positive 20 days after report
- 6 of 8
Analysts
- Consensus price target
- $50.40
- Target vs current price
- +33.7%
- Analysts with a rating
- 9
- Share rating Buy or Strong Buy
- 100%
- Consensus rating
- Buy
How the stock reacted to recent reports
| Report date | EPS surprise | 2 days | 5 days | 20 days | 60 days |
|---|---|---|---|---|---|
| Aug 10, 2026 | +31.9% | +0.1% | +14.6% | -5.4% | — |
| May 12, 2026 | +62.7% | +5.4% | +11.6% | +31.6% | +67.7% |
| Mar 9, 2026 | -4.3% | +1.0% | -12.6% | -13.9% | +4.0% |
| Nov 10, 2025 | -147.4% | -2.2% | +25.7% | +40.2% | +32.0% |
| Aug 11, 2025 | -1020.0% | -1.7% | +0.3% | +25.5% | +71.5% |
| May 15, 2025 | -28.9% | -0.4% | -10.8% | +2.5% | +13.1% |
| Mar 27, 2025 | +7.2% | +2.4% | -10.6% | +5.2% | +71.5% |
| Nov 21, 2024 | -912.0% | -3.2% | +10.1% | +4.0% | -73.8% |
Returns from the close before each report. Past reactions do not determine future ones.
Earnings history
| Report date | EPS | Estimate | Surprise | Revenue |
|---|---|---|---|---|
| Aug 10, 2026 | -$0.29 | -$0.43 | +31.9% | $26.7M |
| May 12, 2026 | -$0.19 | -$0.51 | +62.7% | $26.5M |
| Mar 9, 2026 | -$0.24 | -$0.23 | -4.3% | $24.1M |
| Nov 10, 2025 | -$0.09 | $0.19 | -147.4% | $21.5M |
| Aug 11, 2025 | -$0.56 | -$0.05 | -1020.0% | $119,000 |
| May 15, 2025 | -$0.49 | -$0.38 | -28.9% | $219,000 |
| Mar 27, 2025 | -$0.64 | -$0.69 | +7.2% | $212,000 |
| Nov 21, 2024 | -$8.40 | -$0.83 | -912.0% | $176,000 |
Valuation in context
| Multiple | Now | 5-year median | 5-year percentile | Sector rank (cheapness) |
|---|---|---|---|---|
| EV / Sales | 16.56× | — | — | Bottom 23% |
| Free-cash-flow yield | 6.18% | — | — | Top 14% |
| Earnings yield | -1.43% | — | — | Top 33% |
Technical state
Trend checklist
- ✗ Price above 20-day average
- ✗ Price above 50-day average
- ✓ Price above 200-day average
- ✓ 50-day average above 200-day
- ✗ MACD histogram positive
Trend quality
- Days above the 50-day average
- 0
- Days above the 200-day average
- 273
- 50-day average slope (20 days)
- +4.3%
- 200-day average slope (20 days)
- +4.2%
- Distance from 50-day average
- -3.5%
- Distance from 200-day average
- +22.1%
- RSI (14)
- 45.3
- Relative volume
- 1.13×
Risk and drawdowns
- Volatility, 60 days (annualized)
- 66.1%
- Volatility vs own 5-year history
- 41th percentile · Normal for this stock
- Beta vs S&P 500 (2 years, weekly)
- 2.09
- Correlation with S&P 500
- 0.38
- Current drawdown from 1-year high
- -21.7%
- Maximum drawdown, 3 years
- -81.5%
Largest declines in the past six years
| From peak | To low | Decline | Length | Recovery |
|---|---|---|---|---|
| Dec 23, 2024 | Apr 1, 2025 | -81.5% | 66 days | 164 days (Nov 24, 2025) |
| Feb 24, 2026 | Apr 10, 2026 | -25.2% | 32 days | 33 days (May 28, 2026) |
| Aug 12, 2026 | Sep 4, 2026 | -23.7% | 17 days | Not yet recovered |
| Dec 19, 2025 | Jan 30, 2026 | -21.1% | 27 days | 11 days (Feb 17, 2026) |
| Dec 4, 2024 | Dec 16, 2024 | -16.8% | 8 days | 5 days (Dec 23, 2024) |
Declines of 10% or more from a closing high, measured on daily closes.
Financial statements
- Market cap
- $1.70B
- EPS, diluted (TTM)
- -$0.54
- Revenue (TTM)
- $98.9M
- 52-week range
- $17.55 – $51.10
| FY 2023 | FY 2024 | FY 2025 | |
|---|---|---|---|
| Revenue | $151,000 | $1.1M | $46.0M |
| Gross profit | $151,000 | $1.1M | $46.0M |
| Operating income | $2.1M | -$80.8M | -$80.8M |
| Net income | $4.2M | -$71.8M | -$48.9M |
| EPS (diluted) | $0.03 | -$1.93 | -$1.10 |
| Q3 2024 | Q4 2024 | Q1 2025 | Q2 2025 | Q3 2025 | Q4 2025 | Q1 2026 | Q2 2026 | |
|---|---|---|---|---|---|---|---|---|
| Revenue | $176,000 | $212,000 | $219,000 | $119,000 | $21.5M | $24.1M | $26.5M | $26.7M |
| Net income | -$20.5M | -$20.7M | -$21.5M | -$24.8M | $8.2M | -$10.7M | -$8.6M | -$13.0M |
| EPS (diluted) | -$0.49 | -$0.64 | -$0.49 | -$0.56 | $0.18 | -$0.24 | -$0.19 | -$0.29 |
| FY 2022 | FY 2023 | FY 2024 | FY 2025 | |
|---|---|---|---|---|
| Operating cash flow | -$23.3M | -$38.7M | -$67.5M | $110.2M |
| Capital expenditure | -$1.3M | -$2.9M | -$2.1M | -$518,000 |
| Free cash flow | -$24.6M | -$41.6M | -$69.6M | $109.7M |
| Dividends paid | $0 | $0 | $0 | $0 |
| Net share buybacks | $82,000 | -$1,000 | $302.8M | $1.7M |
Cash outflows are shown as negative numbers.
- Cash and short-term investments
- $372.3M
- Total assets
- $566.7M
- Total liabilities
- $180.0M
- Total debt
- $22.5M
- Net debt
- -$62.1M
- Shareholders’ equity
- $386.7M
As of Jun 30, 2026 (filed Aug 10, 2026).
Short interest
- Shares sold short
- 2,894,002
- Days to cover
- 9.54
- Change vs previous report
- +6.5%
FINRA short interest, settlement date Sep 15, 2026.