Stocks · Healthcare · Biotechnology
Syndax Pharmaceuticals, Inc. SNDX
$17.60 -3.40% Close, Oct 2, 2026 · NASDAQ · Market cap $1.56B
Next earnings report: Nov 2, 2026
Scroll or pinch to zoom, drag to move. Daily prices adjusted for splits. Markers: E = earnings (green beat, red miss), S = split, D = dividend.
Three things to know
- Revenue over the last four quarters was $252.0M, up 222.3% from a year earlier, slowing from 396.7% a quarter earlier.
- Operating margin widened to -77.1% from -433.7% a year earlier.
- The stock is in a downtrend: below its 200-day average, with the 50-day average below the 200-day.
PromtFinance scores
Each score is a percentile within the Healthcare sector (0–100). Under each score: how the stock ranks in its sector on every component. As of Oct 5, 2026.
How fast revenue, earnings and cash flow are growing.
- Revenue growth (TTM, YoY)Top 6%
- Revenue growth accelerationBottom 2%
Returns on capital, margins, earnings quality and balance-sheet strength.
- Return on invested capitalBottom 40%
- Gross marginTop 10%
- Operating marginBottom 32%
- Accruals (lower is better)Bottom 18%
- Interest coverBottom 49%
How cheap the shares are relative to earnings, cash flow and their own history.
- Earnings yieldBottom 39%
- Free-cash-flow yieldBottom 31%
- EBITDA / enterprise valueBottom 44%
- Sales / enterprise valueBottom 38%
Strength and persistence of the price trend, including versus the S&P 500.
- 12-month return excluding last monthTop 42%
- 6-month returnBottom 17%
- 1-year return vs S&P 500Top 50%
- Distance from 52-week highTop 49%
- Trend checklist (0–4)Bottom 14%
Earnings surprises and analyst sentiment (estimate-revision history is being collected).
- Average EPS surprise, last 4 quartersBottom 31%
- Consecutive EPS beatsBottom 20%
- Share of analysts rating BuyTop 26%
- Upside to consensus price targetTop 36%
Low volatility, shallow drawdowns, low market sensitivity and modest leverage.
- Volatility, 60 days (lower is better)Top 26%
- Maximum drawdown, 3 yearsTop 42%
- Beta vs S&P 500 (lower is better)Top 47%
What changed
Latest four quarters versus the same period a year earlier (growth: versus one quarter earlier).
| Measure | Before | Now | |
|---|---|---|---|
| Revenue growth (YoY) | 396.7% | 222.3% | ↓ |
| Gross margin | 97.2% | 97.5% | ↑ |
| Operating margin | -433.7% | -77.1% | ↑ |
| FCF margin | -387.1% | -87.6% | ↑ |
Fundamental momentum
| Measure | Now (TTM) | Year / quarter before | Sector rank | |
|---|---|---|---|---|
| Revenue growth (TTM, YoY) | 222.3% | 396.7% | ↓ | Top 6% |
| Gross margin | 97.5% | 97.2% | ↑ | Top 10% |
| Operating margin | -77.1% | -433.7% | ↑ | Bottom 32% |
| Net margin | -87.6% | -428.5% | ↑ | — |
| Free-cash-flow margin | -87.6% | -387.1% | ↑ | — |
| Return on invested capital | -32.1% | — | Bottom 40% |
Quality of earnings and balance sheet
- Accruals (net income − OCF) / assetsLower is better; high accruals can signal weaker earnings quality.
- -0.0%
- Stock-based compensation / revenueA cost to shareholders through dilution.
- 19.6%
- Receivables growth vs revenue growthReceivables growing much faster than sales can be a warning.
- -134.9 pp
- Interest cover (operating income / interest)How many times operating profit covers interest.
- -2.3×
Shareholder returns
- Dividend yield (dividends paid, TTM)
- 0.00%
- Net buyback yield (TTM)
- -1.82%
- Shareholder yield
- -1.82%
- Share count change, 1 year
- +3.1%
- Share count change, 3-year CAGR
- +8.5%
Shareholder yield = dividends + net buybacks over the last four quarters, divided by market cap.
Based on the four quarters through Jun 30, 2026 (filed Aug 4, 2026).
Earnings and expectations
Earnings momentum
- Consecutive EPS beats
- 0
- Beats in the last 8 reports
- 5 of 8
- Average EPS surprise, last 4
- -8.1%
- Average 2-day reaction, last 8
- +1.1%
- Positive 20 days after report
- 4 of 8
Analysts
- Consensus price target
- $36.67
- Target vs current price
- +108.4%
- Analysts with a rating
- 22
- Share rating Buy or Strong Buy
- 91%
- Consensus rating
- Buy
How the stock reacted to recent reports
| Report date | EPS surprise | 2 days | 5 days | 20 days | 60 days |
|---|---|---|---|---|---|
| Aug 4, 2026 | -22.9% | -0.8% | +5.9% | +0.3% | — |
| Apr 30, 2026 | +18.6% | +3.9% | +0.1% | -4.3% | -0.5% |
| Feb 26, 2026 | -33.6% | -0.4% | +4.2% | +16.6% | -4.7% |
| Nov 3, 2025 | +5.4% | +0.4% | +9.8% | +39.6% | +50.3% |
| Aug 4, 2025 | +17.0% | +4.0% | +25.1% | +63.6% | +31.4% |
| May 5, 2025 | +5.8% | -1.2% | -22.1% | -20.0% | -27.2% |
| Mar 3, 2025 | -1.9% | -1.0% | -14.2% | -15.7% | -36.5% |
| Nov 5, 2024 | +13.3% | +4.0% | +15.0% | -12.2% | -24.3% |
Returns from the close before each report. Past reactions do not determine future ones.
Earnings history
| Report date | EPS | Estimate | Surprise | Revenue |
|---|---|---|---|---|
| Aug 4, 2026 | -$0.55 | -$0.45 | -22.9% | $72.8M |
| Apr 30, 2026 | -$0.48 | -$0.59 | +18.6% | $64.9M |
| Feb 26, 2026 | -$0.78 | -$0.58 | -33.6% | $68.7M |
| Nov 3, 2025 | -$0.70 | -$0.74 | +5.4% | $45.9M |
| Aug 4, 2025 | -$0.83 | -$1.00 | +17.0% | $38.0M |
| May 5, 2025 | -$0.98 | -$1.04 | +5.8% | $20.0M |
| Mar 3, 2025 | -$1.10 | -$1.08 | -1.9% | $7.7M |
| Nov 5, 2024 | -$0.98 | -$1.13 | +13.3% | $12.5M |
Valuation in context
| Multiple | Now | 5-year median | 5-year percentile | Sector rank (cheapness) |
|---|---|---|---|---|
| EV / Sales | 7.19× | — | — | Bottom 38% |
| Free-cash-flow yield | -14.16% | — | — | Bottom 31% |
| Earnings yield | -14.32% | — | — | Bottom 39% |
Technical state
Trend checklist
- ✗ Price above 20-day average
- ✗ Price above 50-day average
- ✗ Price above 200-day average
- ✗ 50-day average above 200-day
- ✓ MACD histogram positive
Trend quality
- Days above the 50-day average
- 0
- Days above the 200-day average
- 0
- 50-day average slope (20 days)
- -7.9%
- 200-day average slope (20 days)
- -0.4%
- Distance from 50-day average
- -8.7%
- Distance from 200-day average
- -15.7%
- RSI (14)
- 40.6
- Relative volume
- 1.40×
Risk and drawdowns
- Volatility, 60 days (annualized)
- 42.4%
- Volatility vs own 5-year history
- 17th percentile · Low for this stock
- Beta vs S&P 500 (2 years, weekly)
- 1.05
- Correlation with S&P 500
- 0.26
- Current drawdown from 1-year high
- -30.0%
- Maximum drawdown, 3 years
- -64.8%
Largest declines in the past six years
| From peak | To low | Decline | Length | Recovery |
|---|---|---|---|---|
| Feb 1, 2023 | Jul 7, 2025 | -69.9% | 607 days | Not yet recovered |
| Dec 21, 2020 | Apr 20, 2021 | -49.2% | 81 days | 437 days (Jan 12, 2023) |
| Oct 16, 2020 | Oct 22, 2020 | -14.0% | 4 days | 3 days (Oct 27, 2020) |
| Nov 5, 2020 | Nov 11, 2020 | -12.4% | 4 days | 3 days (Nov 16, 2020) |
Declines of 10% or more from a closing high, measured on daily closes.
Financial statements
- Market cap
- $1.56B
- EPS, diluted (TTM)
- -$2.52
- Revenue (TTM)
- $252.0M
- 52-week range
- $12.99 – $25.59
| FY 2021 | FY 2022 | FY 2023 | FY 2024 | FY 2025 | |
|---|---|---|---|---|---|
| Revenue | $139.7M | $0 | $0 | $23.7M | $172.4M |
| Gross profit | $139.7M | $0 | $0 | $22.9M | $165.4M |
| Operating income | $26.2M | -$151.8M | -$230.0M | -$339.7M | -$273.1M |
| Net income | $24.9M | -$149.3M | -$209.4M | -$318.8M | -$285.4M |
| EPS (diluted) | $0.48 | -$2.46 | -$2.98 | -$3.73 | -$3.29 |
| Q3 2024 | Q4 2024 | Q1 2025 | Q2 2025 | Q3 2025 | Q4 2025 | Q1 2026 | Q2 2026 | |
|---|---|---|---|---|---|---|---|---|
| Revenue | $12.5M | $7.7M | $20.0M | $38.0M | $45.9M | $68.5M | $64.9M | $72.8M |
| Net income | -$84.1M | -$94.2M | -$84.8M | -$71.8M | -$60.7M | -$68.0M | -$42.7M | -$49.4M |
| EPS (diluted) | -$0.98 | -$1.10 | -$0.99 | -$0.83 | -$0.70 | -$0.78 | -$0.49 | -$0.55 |
| FY 2021 | FY 2022 | FY 2023 | FY 2024 | FY 2025 | |
|---|---|---|---|---|---|
| Operating cash flow | $29.1M | -$133.7M | -$160.6M | -$274.9M | -$323.0M |
| Capital expenditure | -$129,000 | -$225,000 | $0 | $0 | -$187,000 |
| Free cash flow | $29.0M | -$133.9M | -$160.6M | -$274.9M | -$323.2M |
| Dividends paid | $0 | $0 | $0 | $0 | $0 |
| Net share buybacks | $86.3M | $181.4M | $258.1M | $9.7M | $13.7M |
Cash outflows are shown as negative numbers.
- Cash and short-term investments
- $547.9M
- Total assets
- $703.7M
- Total liabilities
- $688.6M
- Total debt
- $589.4M
- Net debt
- $252.9M
- Shareholders’ equity
- $15.1M
As of Jun 30, 2026 (filed Aug 4, 2026).
Short interest
- Shares sold short
- 20,660,449
- Days to cover
- 14.73
- Change vs previous report
- -4.7%
FINRA short interest, settlement date Sep 15, 2026.